Formulation of Low-substituted Hydroxypropyl Cellulose as an Anti-Capping Agent in Paracetamol Wet-Granulated Tablets

Arry Andika Wibawa; Alhara Yuwanda; Nopratilova; Dewi Rahmawati

doi:10.56904/jgpr.v1i01.113

Authors

Arry Andika Wibawa Department of Pharmacy, Faculty of Pharmacy, Jakarta Global University, Depok, West Java, Indonesia 16412
Alhara Yuwanda Department of Pharmacy, Faculty of Pharmacy, Jakarta Global University, Depok, West Java, Indonesia 16412
Nopratilova Department of Pharmacy, Faculty of Pharmacy, Jakarta Global University, Depok, West Java, Indonesia 16412
Dewi Rahmawati Department of Pharmacy, Faculty of Pharmacy, Jakarta Global University, Depok, West Java, Indonesia 16412

DOI:

https://doi.org/10.56904/jgpr.v1i01.113

Keywords:

paracetamol, low HPC 11, tablet capping, wet granulation

Abstract

Paracetamol has poor flow and compressibility, this causes the potential for tablet capping in its manufacture. Low substituted hydroxypropyl cellulose (Low HPC 11) considered in this study was used as a binder in tablets with capping potential. By wet granulation, Low HPC 11 was made with different concentrations, namely F1 0%, F2 0.5%, F3 1% and F4 2%, to determine compression behavior and the effect on the resulting tablet. The results of the evaluation showed that an increase in the concentration of Low HPC 11 caused an increase in the value of hardness, longer disintegration time, a decrease in the value of tablet friability and minimized the potential for capping of the resulting tablet. At a concentration of Low HPC 11 2% produced the best quality tablets with a hardness value of 14.65 ± 0.6 Kp, tablet friability 0.13%, disintegration time 2.73 minutes with no symptoms of capping.

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